Acamprosate (Campral) does what to GABA and glutamate levels?

Acamprosate (Campral) does what to GABA and glutamate levels?

• A. Raises GABA and lowers glutamate
• B. Raises glutamate and lowers GABA
• C. No effect on GABA or glutamate
• D. Lowers both GABA and glutamate

Answer: (A)

Acamprosate helps rebalance brain signaling after chronic alcohol exposure by boosting inhibitory GABA activity while dampening excitatory glutamatergic activity. This dual action reduces withdrawal hyperexcitability and craving, contributing to relapse prevention. Clinically, it is described as increasing GABA effects and lowering glutamate activity, rather than having no effect or the opposite pattern.

Acamprosate helps rebalance brain signaling after chronic alcohol exposure by boosting inhibitory GABA activity while dampening excitatory glutamatergic activity. This dual action reduces withdrawal hyperexcitability and craving, contributing to relapse prevention. Clinically, it is described as increasing GABA effects and lowering glutamate activity, rather than having no effect or the opposite pattern.