Amphetamines increase the activity of which neurotransmitters?

Amphetamines increase the activity of which neurotransmitters?

• A. Acetylcholine and GABA
• B. Dopamine and norepinephrine
• C. Serotonin and glutamate
• D. GABA and glutamate

Answer: (B)

Amphetamines act by boosting monoamine transmission, with the strongest effects seen on dopamine and norepinephrine. They promote release and blockage of reuptake for these neurotransmitters, mainly through actions on DAT and NET and by driving vesicular release. This leads to the hallmark stimulant effects: increased alertness, mood elevation, and sympathetic arousal (tachycardia, hypertension). Serotonin can be affected, but to a lesser extent that is not the primary mechanism, while acetylcholine, GABA, and glutamate are not the main targets. So the neurotransmitters whose activity is most increased are dopamine and norepinephrine.

Amphetamines act by boosting monoamine transmission, with the strongest effects seen on dopamine and norepinephrine. They promote release and blockage of reuptake for these neurotransmitters, mainly through actions on DAT and NET and by driving vesicular release. This leads to the hallmark stimulant effects: increased alertness, mood elevation, and sympathetic arousal (tachycardia, hypertension). Serotonin can be affected, but to a lesser extent that is not the primary mechanism, while acetylcholine, GABA, and glutamate are not the main targets. So the neurotransmitters whose activity is most increased are dopamine and norepinephrine.