LSD is a hallucinogen that elevates activity of which neurotransmitter system?

LSD is a hallucinogen that elevates activity of which neurotransmitter system?

• A. Dopamine
• B. Serotonin
• C. GABA
• D. Norepinephrine

Answer: (B)

LSD’s primary action is on the serotonin system, functioning as a potent agonist at 5-HT2A receptors in cortical and perceptual brain regions. Activating these receptors increases excitatory signaling in cortical circuits, especially in areas involved with perception and thought, which leads to the vivid visual distortions and altered cognition characteristic of LSD. While other neurotransmitter systems can be influenced, the psychedelic experience is driven mainly by serotonergic stimulation, not dopamine, GABA, or norepinephrine.

LSD’s primary action is on the serotonin system, functioning as a potent agonist at 5-HT2A receptors in cortical and perceptual brain regions. Activating these receptors increases excitatory signaling in cortical circuits, especially in areas involved with perception and thought, which leads to the vivid visual distortions and altered cognition characteristic of LSD. While other neurotransmitter systems can be influenced, the psychedelic experience is driven mainly by serotonergic stimulation, not dopamine, GABA, or norepinephrine.